Entwicklung von Silber-Nanopartikeln für Krebs-Targeting

Stipendiatin/Stipendiat: PhD Studen Abdalrahim Alahmad

Over the past decade there has been an increased interest on the topic of “green” chemistry applied to chemical processes. These efforts aim at the total elimination or at least the minimization of generated waste and the implementation of sustainable processes through the adoption of 12 fundamental principles (which are: Atom Economy, Prevention, Less Hazardous Chemical Syntheses, Designing Safer Chemicals, Safer Solvents and Auxiliaries, Design for Energy Efficiency, Use of Renewable Feedstocks, Reduce Derivatives, Catalysis, Design for Degradation, Real-time Analysis for Pollution Prevention and Inherently Safer Chemistry for Accident Prevention). Any attempt to reach these goals must comprehensively address these principles in the design of a synthetic route, chemical analysis, or chemical process. Utilization of nontoxic chemicals, environmentally acceptable solvents, and renewable materials are some of the key issues that merit important considerations in a green synthetic strategy. In the present work, we present a totally green approach toward the synthesis and stabilization of metal nanoparticles. Produced nanoparticles will be investigated for their applicability in biomedical applications especially in cancer therapy. In our study, we will focus on finding a novel green synthesis routes for silver nanoparticles (AgNPs) using different extracts from a variety of medicinal plants. The aim of this study is the investigation of the anti-cancer activities and antiproliferative activities of the bioactive AgNPs along with their capping biomolecules in vitro. Prerequisite for every possible application is the proper surface functionalization of these nanoparticles, which determines their interaction with the environment (such as cancer cells), so one focus of this research study is the development of surface modification strategies and functionalization of silver colloidal nanoparticles for later in vivo applications. Especially the study of functionalization of silver nanoparticles with biomolecules still needs intensive studies. So we will try to achieve mechanistic insights by careful characterization of produced nanoparticles. Therefore, the obtained product in each stage of the work will be characterized by X-ray diffraction (XRD), energy dispersive X-ray (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-visible absorption spectroscopy, dynamic light scattering (DLS), and zeta potential measurement. 

Förderzeitraum:
01.12.2016 - 31.03.2017

Institut:
Leibniz Universität Hannover
Zentrum für Angewandte Chemie
Institut für Technische Chemie

Betreuer:
Prof. Dr. Thomas Scheper

E-Mail: E-Mail schreiben

Publikationen:

  • Preparation of colloidal silver nanoparticles and structural characterization
    Arruebo M, Pacheco RF, Ibarra MR, Santamaria J, 2007. Magnetic nanoparticles for drug delivery. Nanotoday, 2:22-32. Bae CH, Nam SH, Park SM, 2002. Formation of silver nanoparticles by laser ablation of silver target in NaCl solution. Appl Surf Sci, 197-198, 628-634. Chou K-S, Lai Y-S, 2004. Effect of polyvinyl pyrrolidone molecular weights on the formation of nanosized silver colloids. Mater Chem Phys, 83(1): p. 82-88. Chou K-S, Lu Y-C, Lee H-H, 2005. Effect of alkaline ion on the mechanism and
  • Colloidal Synthesis and Structural Characterizations of Silver Nanoparticles by using Wet Chemistry
    1. Mohd Abdul Majeed Khan, Sushil Kumar, Maqusood Ahamed, Salman A Alrokayan and Mohammad Saleh AlSalhi, “Structural and thermal studies of silver nanoparticles and electrical transport study of their thin films”, Nanoscale Research Letters (2011), 6:434. 2. M. Shao, L. Lu, H. Wang, S. Luo & D. D. Ma, “Microfabrication of a new sensor based on silver and silicon nanomaterials, and its application to the enrichment and detection of bovine serum albumin via surface-enhanced Raman scattering”, Micr
  • Preparation and Characterization of Silver Nanoparticles
    1. Handbook of Nanofabrication. 2010, Amsterdam: Elsevier. 2. Daniel, M.C. and D. Astruc, Gold nanoparticles: Assembly, supramolecular chemistry, quantumsizerelated properties, and applications toward biology, catalysis, and nanotechnology. Chemical Reviews, 2004. 104: p. 239-346. 3. Pérez-Juste, J., et al., Gold nanorods: Synthesis, characterization and applications. Coordination Chemistry Reviews, 2005. 249: p. 1870-1901. 4. Lu, A.H., E.L. Salabas, and F. Schuth, Magnetic nanoparticles: Synthe